abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two distinct forms of synaptic plasticity that have been extensively characterized at the Schaffer collateral-CA1 (SCCA1) synapse and the mossy fiber (MF)-CA3 synapse within the hippocampus, and are postulated to be the molecular underpinning for several ...

journal_title：Current neuropharmacology

authors： Senter RK,Ghoshal A,Walker AG,Xiang Z,Niswender CM,Conn PJ

更新日期：2016-01-01 00:00:00

abstract：:In the recent years we have been observing an increased incidence of type 1 diabetes in children and adolescents. This leads to a more frequent acute complication of type 1 diabetes among children with hyperglycemia. The most common of these is diabetic ketoacidosis (DKA), while cerebral edema is the most dangerous. I...

journal_title：Current neuropharmacology

authors： Szmygel Ł,Kosiak W,Zorena K,Myśliwiec M

更新日期：2016-01-01 00:00:00

abstract：:Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects in autophagy are critically associated with mechanisms underlying Parkinson's disease (PD), a common and debilitating neurodegenerative disorder. Autophagic dysfunction in PD can occur at several stages of the autophagy/lysosom...

journal_title：Current neuropharmacology

authors： Rivero-Ríos P,Madero-Pérez J,Fernández B,Hilfiker S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Depression is among the commonest of psychiatric disorders, and inflammatory mechanisms have been suggested to play a role in its pathophysiology. Interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms. Interferons are used in the treatment of a variety of auto...

journal_title：Current neuropharmacology

authors： Pinto EF,Andrade C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is an important complication of diabetes and is considered one of the main causes of blindness in moderate-income and highly-developed countries. As it is a major socioeconomic problem, defining all mechanisms that may lead to DR development is of great importance. In the 21st centu...

journal_title：Current neuropharmacology

authors： Mrugacz M,Bryl A,Bossowski A

更新日期：2016-01-01 00:00:00

abstract：:Several lines of evidence indicate that rats emit ultrasonic vocalizations (USVs) in response to a wide range of stimuli that are capable of producing either euphoric (positive) or dysphoric (negative) emotional states. On these bases, recordings of USVs are extensively used in preclinical studies of affect, motivatio...

journal_title：Current neuropharmacology

authors： Simola N

更新日期：2015-01-01 00:00:00

abstract：:The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors. Several members of the TRP family are sensitive to oxidative stress mediators. Among them, TRPA1 is remarkably susceptible to various oxidants, and is known to mediate neuropathic pain and respiratory, vascular a...

journal_title：Current neuropharmacology

authors： Kozai D,Sakaguchi R,Ohwada T,Mori Y

更新日期：2015-01-01 00:00:00

abstract：:Depression is a serious psychiatric illness that affects millions of people worldwide. Weeks of antidepressant therapy are required to relieve depressive symptoms, and new drugs are still being extensively researched. The latest studies have shown that in depression, there is an imbalance between the main excitatory (...

journal_title：Current neuropharmacology

authors： Mlyniec K

更新日期：2015-01-01 00:00:00

abstract：:New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamp...

journal_title：Current neuropharmacology

authors： Karila L,Megarbane B,Cottencin O,Lejoyeux M

更新日期：2015-01-01 00:00:00

abstract：:During the last decade, several meta-analytic studies employing different methodological approaches have had inconsistent conclusions regarding antidepressant efficacy. Herein, we aim to comment on methodological aspects that may have contributed to disparate findings. We initially discuss methodological inconsistenci...

journal_title：Current neuropharmacology

authors： Fountoulakis KN,McIntyre RS,Carvalho AF

更新日期：2015-01-01 00:00:00

abstract：:The push-pull superfusion technique (PPST) is a procedure for in vivo examination of transmitter release in distinct brain areas. This technique allows to investigate dynamics of transmitter release both under normal and experimentally evoked conditions. The PPST can be modified so that it is possible to determine rel...

journal_title：Current neuropharmacology

authors： Kraus MM,Philippu A

更新日期：2015-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a common progressive, neurodegenerative brain disease that is promoted by mitochondrial dysfunction, oxidative stress, protein aggregation and proteasome dysfunction in the brain. Compared with computer tomography (CT) or magnetic resonance imaging (MRI), non-invasive nuclear radiopharmaceu...

journal_title：Current neuropharmacology

authors： Wu X,Cai H,Ge R,Li L,Jia Z

更新日期：2014-12-01 00:00:00

abstract：:In preclinical neuropharmacological research, molecular, cell-based, and systems using animals are well established. On the tissue level the situation is less comfortable, although during the last decades some effort went into establishing such systems, i.e. using slices of the vertebrate brain together with optical a...

journal_title：Current neuropharmacology

authors： V M Fde L,W H

更新日期：2014-09-01 00:00:00

abstract：:Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmo...

journal_title：Current neuropharmacology

authors： Montana V,Verkhratsky A,Parpura V

更新日期：2014-07-01 00:00:00

abstract：:Over the last decades, the scientific interest in chemistry and pharmacology of cannabinoids has increased. Most attention has focused on ∆(9)-tetrahydrocannabinol (∆(9)-THC) as it is the psychoactive constituent of Cannabis sativa (C. sativa). However, in previous years, the focus of interest in the second plant cons...

journal_title：Current neuropharmacology

authors： Murillo-Rodríguez E,Sarro-Ramírez A,Sánchez D,Mijangos-Moreno S,Tejeda-Padrón A,Poot-Aké A,Guzmán K,Pacheco-Pantoja E,Arias-Carrión O

更新日期：2014-05-01 00:00:00

abstract：:Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS) has been classified as a disease of the central nervous system by the WHO since 1969. Many patients carrying this diagnosis do demonstrate an almost bewildering array of biological abnormalities particularly the presence of oxidative and nitrosative stres...

journal_title：Current neuropharmacology

authors： Morris G,Maes M

更新日期：2014-03-01 00:00:00

abstract：:Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as m...

journal_title：Current neuropharmacology

authors： Luo J,Walters ET,Carlton SM,Hu H

更新日期：2013-12-01 00:00:00

abstract：:It is well recognized the role of the Wnt pathway in many developmental processes such as neuronal maturation, migration, neuronal connectivity and synaptic formation. Growing evidence is also demonstrating its function in the mature brain where is associated with modulation of axonal remodeling, dendrite outgrowth, s...

journal_title：Current neuropharmacology

authors： Ortiz-Matamoros A,Salcedo-Tello P,Avila-Muñoz E,Zepeda A,Arias C

更新日期：2013-09-01 00:00:00

abstract：:As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery o...

journal_title：Current neuropharmacology

authors： Murray AP,Faraoni MB,Castro MJ,Alza NP,Cavallaro V

更新日期：2013-07-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought to serve as a key relay connecting limbic forebrain structures to hypothalamic and brainstem reg...

journal_title：Current neuropharmacology

authors： Crestani CC,Alves FH,Gomes FV,Resstel LB,Correa FM,Herman JP

更新日期：2013-03-01 00:00:00

abstract：:The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, an...

journal_title：Current neuropharmacology

authors： Ferrucci M,Giorgi FS,Bartalucci A,Busceti CL,Fornai F

更新日期：2013-01-01 00:00:00

abstract：:Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience rese...

journal_title：Current neuropharmacology

authors： Khanbabaie R,Jahanshahi M

更新日期：2012-12-01 00:00:00

abstract：:Malignant glioma is the most common and destructive form of primary brain tumor. Along with surgery and radiation, chemotherapy remains as the major treatment modality. The emergence of drug resistance, however, often leads to a therapeutic failure in the treatment of glioma, precluding long-term survival of the patie...

journal_title：Current neuropharmacology

authors： Suk K

更新日期：2012-03-01 00:00:00

abstract：:The heat shock protein (Hsp) family is an evolutionarily conserved system that is charged with preventing unfolded or misfolded proteins in the cell from aggregating. In Alzheimer's disease, extracellular accumulation of the amyloid β peptide (Aβ) and intracellular aggregation of the microtubule associated protein tau...

journal_title：Current neuropharmacology

authors： Abisambra JF,Jinwal UK,Jones JR,Blair LJ,Koren J 3rd,Dickey CA

更新日期：2011-12-01 00:00:00

abstract：:Ion channels are complex transmembrane proteins that orchestrate the electrical signals necessary for normal function of excitable tissues, including the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. Progress in molecular biology has allowed cloning and expression of genes that encode...

journal_title：Current neuropharmacology

authors： Kleopa KA

更新日期：2011-09-01 00:00:00

abstract：:During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare p...

journal_title：Current neuropharmacology

authors： Carletti B,Piemonte F,Rossi F

更新日期：2011-06-01 00:00:00

abstract：:Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in the nucleus accumbens (and/or in other places). On the other hand, there is a relationship between dopamine and all behavioural aspects that involve motor activity and it has been dem...

journal_title：Current neuropharmacology

authors： Fontes-Ribeiro CA,Marques E,Pereira FC,Silva AP,Macedo TR

更新日期：2011-03-01 00:00:00

abstract：:MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway,...

journal_title：Current neuropharmacology

authors： Takamatsu Y,Shiotsuki H,Kasai S,Sato S,Iwamura T,Hattori N,Ikeda K

更新日期：2011-03-01 00:00:00

abstract：:Drug addiction results from the interplay between social and biological factors. Among these, genetic variables play a major role. The use of genetically related inbred rat strains that differ in their preference for drugs of abuse is one approach of great importance to explore genetic determinants. Lewis and Fischer ...

journal_title：Current neuropharmacology

authors： Higuera-Matas A,Montoya GL,Coria SM,Miguéns M,García-Lecumberri C,Ambrosio E

更新日期：2011-03-01 00:00:00

abstract：:To explore the functional consequences of cannabinoid withdrawal in the rat mesolimbic dopamine system, we investigated the anatomical morphology of the mesencephalic, presumed dopaminergic, neurons and their main post-synaptic target in the Nucleus Accumbens. We found that TH-positive neurons shrink and Golgi-stained...

journal_title：Current neuropharmacology

authors： Spiga S,Lintas A,Diana M

更新日期：2011-03-01 00:00:00

abstract：:Ketamine is a noncompetitive antagonist of the NMDA-receptors, used as a dissociative anesthetic, presently included in the category of the psychoactive substances known as "club drugs". Ketamine administration was associated with impaired working memory and increased psychopathological symptoms, but there is a lack o...

journal_title：Current neuropharmacology

authors： Venâncio C,Magalhães A,Antunes L,Summavielle T

更新日期：2011-03-01 00:00:00

abstract：:Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these co...

journal_title：Current neuropharmacology

authors： Azari MF,Mathias L,Ozturk E,Cram DS,Boyd RL,Petratos S

更新日期：2010-12-01 00:00:00

abstract：:Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage inflicted is usually a consequence of the ability of these toxic agents to induce free radical generation within cells but especially at the level of the mitochondria. The elevated production of oxygen and nitrogen-based radical...

journal_title：Current neuropharmacology

authors： Reiter RJ,Manchester LC,Tan DX

更新日期：2010-09-01 00:00:00

abstract：:Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in ...

journal_title：Current neuropharmacology

authors： Buffoli B

更新日期：2010-06-01 00:00:00

abstract：:Many issues remain unresolved about antipsychotic drugs. Their therapeutic potency scales with affinity for dopamine D2 receptors, but there are indications that they act indirectly, with dopamine D1 receptors (and others) as possible ultimate targets. Classical neuroleptic drugs disinhibit striatal cholinergic intern...

journal_title：Current neuropharmacology

authors： Miller R

更新日期：2009-12-01 00:00:00

abstract：:The 'omnipresence' of adenosine in all nervous system cells (neurons and glia) together with the intensive release of adenosine following insults, makes adenosine as a sort of 'maestro' of synapses leading to the homeostatic coordination of brain function. Besides direct actions of adenosine on the neurosecretory mech...

journal_title：Current neuropharmacology

authors： Sebastião AM,Ribeiro JA

更新日期：2009-09-01 00:00:00

abstract：:When discussing AED conversion in the clinic, both the patient and physician perspectives on the goals and risks of this change are important to consider. To identify patient-reported and clinician-perceived concerns, a panel of epilepsy specialists was questioned about the topics discussed with patients and the clini...

journal_title：Current neuropharmacology

authors： Smith BJ,St Louis EK,Stern JM,Green C,Bramley T

更新日期：2009-06-01 00:00:00

abstract：:Changes of the tumor necrosis factor-alpha (TNF-alpha) system have been shown to be involved in the development of psychiatric disorders and are additionally associated with changes in body weight as well as endocrine and metabolic changes in psychiatric patients. TNF-alpha might, for example, contribute to the pathog...

journal_title：Current neuropharmacology

authors： Berthold-Losleben M,Himmerich H

更新日期：2008-09-01 00:00:00

abstract：:Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equally debated is whether they are toxic, protective, or simple by-products. Increasing evidence, however, supports the notion that in general aggregates confer toxicity a...

journal_title：Current neuropharmacology

authors： Bossy B,Perkins G,Bossy-Wetzel E

更新日期：2008-06-01 00:00:00

abstract：:From the initial characterizations of inflammatory responses in Alzheimer's disease (AD) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was...

journal_title：Current neuropharmacology

authors： Walker D,Lue LF

更新日期：2007-12-01 00:00:00